Solid Lipid Nanoparticles Improve the Diclofenac Availability in Vitreous after Intraocular Injection

Table 2

Concentration of diclofenac (µg/mL) in vitreous and aqueous humor samples after intravitreal injection of solid lipid nanoparticles containing diclofenac (mean SD, ). Right eyes and left eyes were injected with solid lipid nanoparticles containing diclofenac and diclofenac commercial injection, respectively (dose = 0.3 mg).

Time (hour)	Vitreous samples		Aqueous humor samples
	Right eyes	Left eyes	Right eyes	Left eyes
1	88.94 13.03	33.47 22.45	10.220 4.943	1.564 0.547
4	58.93 17.86	3.87 2.11	8.661 3.419	1.988 1.469
12	1.94 1.31	0.30 0.22	0.200 0.102	0.181 0.109
24	0.24 0.14	0.12 0.07	0.133 0.041	0.113 0.084
48	0.14 0.01	0.09 0.06	0.076 0.023	0.008 0.007