Poly(lactic-co-glycolic) Acid-Chitosan Dual Loaded Nanoparticles for Antiretroviral Nanoformulations

Table 1

Average size, PDI, zeta potential, and encapsulation efficiency of single and dual drug loaded NPs.

Sample	Components	Size (nm)	Polydispersity index (PDI)	Zeta potential (mV)
1.1	PLGA-CS-LMV	233	0.084	+25
1.2	PLGA-CS-LMV	231	0.072	+19
1.3	PLGA-CS-LMV	240	0.127	+28
1.4	PLGA-CS-LMV	244	0.148	+25
Mean		237	0.108	+24
Std. Dev.		6	0.04	3.9
Average EE%		7.5%
2.1	PLGA-CS-NVP	317	0.314	+18
2.2	PLGA-CS-NVP	250	0.245	+22
2.3	PLGA-CS-NVP	293	0.272	+20
2.4	PLGA-CS-NVP	273	0.206	+22
Mean		283	0.259	+20.4
Std. Dev.		29	0.05	2.0
Average EE%		7.5%
3.1	PLGA-CS-NVP-LMV	246	0.176	+23
3.2	PLGA-CS-NVP-LMV	242	0.131	+25
3.3	PLGA-CS-NVP-LMV	261	0.151	+15
3.4	PLGA-CS-NVP-LMV	220	0.122	+21
Mean		242	0.145	+21
Std. Dev.		17	0.02	4.2
Average EE%		13%
4.1	PLGA-CS	227	0.010	+21
4.2	PLGA-CS	242	0.118	+18
Mean		235	0.064	+20
Std. Dev.		11	0.08	1.8
5.1	PLGA-LMV	278	0.125	−21
6.1	PLGA-NVP	306	0.305	−9