Research Article

Development of Oral Dissolvable Films of Diclofenac Sodium for Osteoarthritis Using Albizia and Khaya Gums as Hydrophilic Film Formers

Table 2

Comparative physicochemical properties of purified Albizia and Khaya gums (mean ± SD, ).

ParameterType of gum
AlbiziaKhaya

Extraction yield (%)39.38 ± 2.3567.50 ± 2.98
Moisture content (%)12.42 ± 2.1013.92 ± 1.51
Insoluble matter (%)0.275 ± 0.0410.282 ± 0.013
pH (1% w/v @ 25°C)5.00 ± 0.123.84 ± 0.09
Total ash (% w/w)7.853 ± 0.0645.603 ± 0.023
Water soluble ash (% w/w)1.303 ± 0.0231.200 ± 0.017
Acid insoluble ash (% w/w)0.600 ± 0.0170.607 ± 0.012
Solubility (%)
 Cold water1.273 ± 0.0640.380 ± 0.020
 Warm water1.747 ± 0.0830.527 ± 0.064
 Acetone 0.110 ± 0.0440.127 ± 0.031
 Chloroform 0.070 ± 0.0620.020 ± 0.020
 Ethanol 0.093 ± 0.0230.087 ± 0.042
Swelling index (%)611.29 ± 4.07477.97 ± 8.67
True density (g/mL)1.363 ± 0.0121.412 ± 0.073
Temperature of charring (°C)258.33 ± 2.89242.67 ± 2.52