Design and Evaluation of Voriconazole Loaded Solid Lipid Nanoparticles for Ophthalmic Application

Table 2

Physiochemical characterization of VCZ loaded solid lipid nanoparticles.

S. number	Batches	Particle size (nm ± SD)	Zeta potential (mV ± SD)	⁢ (±SD)	Entrapment efficiency (%  ± SD)
1	⁢	234 ± 1.52	−22.71 ± 0.63	0.327 ± 0.01	70.26 ± 0.09
2	⁢	247 ± 2.08^††	−27.10 ± 0.55^††	0.192 ± 0.02^††	72.08 ± 0.02^††
3	⁢	265 ± 1.50^††	−25.23 ± 0.56^††	0.261 ± 0.07^†	76.64 ± 0.04^††
4	⁢	274 ± 4.04^††	−24.73 ± 0.61^††	0.291 ± 0.03^†	84.25 ± 0.11^††
5	⁢	288 ± 4.58^††	−28.86 ± 0.58^††	0.232 ± 0.05^†	61.91 ± 0.04^††
6	⁢	308 ± 3.51	−26.46 ± 0.30	0.248 ± 0.04	59.13 ± 0.07^††
7	⁢	319 ± 2.64^†	−27.96 ± 0.41^††	0.188 ± 0.02^†	63.23 ± 0.12^††
8	⁢	325 ± 4.16^††	−24.83 ± 0.65^††	0.337 ± 0.06^†	65.13 ± 0.05^††
9	⁢	335 ± 4.50^††	−23.46 ± 0.40^††	0.219 ± 0.02^†	72.50 ± 0.05^††
10	⁢	343 ± 3.51^††	−28.6 ± 0.36^††	0.263 ± 0.02^†	60.17 ± 0.05^††

⁢: voriconazole loaded solid lipid nanoparticle prepared with ultrasonication method. : voriconazole loaded solid lipid nanoparticle prepared with microemulsion technique.⁢ polydispersity index. Values are mean ±  SD ().
⁢ significant difference at ; significant difference at , from control (VUSLN-4 and VMSLN-9) as determined by one-way ANOVA followed by Dunnett’s test.