Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis

Table 1

Composition of double layer patch by using 3² factorial design.

(a) First Layer

Batches	Benzydamine HCl	HPMC E15 LV	PEG 400	IPA	Dist. water
	(mg)	(mg)	mL	mL	mL
DL1	32.14	600	—	12	8
DL2	32.14	650	0.5	12	8
DL3	32.14	700	1	12	8
DL4	32.14	600	—	12	8
DL5	32.14	650	0.5	12	8
DL6	32.14	700	1	12	8
DL7	32.14	600	—	12	8
DL8	32.14	650	0.5	12	8
DL9	32.14	700	1	12	8

(b) Second layer

Batches	Eudragit RSPO	Eudragit RSPO + EC	Eudragit NE30 D	Acetone	TEC
	mg	mg	mL	mL	%
DL1	1680	—	—	20	—
DL2	1680	—	—	20	2
DL3	1680	—	—	20	3
DL4	—	1428 + 272	—	20	—
DL5	—	1428 + 272	—	20	2
DL6	—	1428 + 272	—	20	3
DL7	—	—	2	—	—
DL8	—	—	2	—	—
DL9	—	—	2	—	—