Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications

Table 2

Steady-state delivery rates for the various channel geometries as compared to the desired dosing rate.

Drug	Design	Flux mol m^−2 s^−1	nmol/day	Desired dosing rate (nmol/day)	Lifetime (years)
Macugen	Snake	2.68E − 06	0.579	6	1.042
	Leaf	1.71E − 05	3.703		0.163
	Straight	6.11E − 05	13.207		0.046
Lucentis	Snake	1.86E − 06	0.401	0.3472	1.503
	Leaf	1.19E − 05	2.567		0.235
	Straight	4.24E − 05	9.157		0.066
Intravitreal Avastin	Snake	1.12E − 06	0.241	0.279	2.500
	Leaf	7.14E − 06	1.543		0.391
	Straight	2.55E − 05	5.503		0.110
Fluocinolone acetonide	Snake	2.05E − 06	0.444	237	1.359
	Leaf	1.31E − 05	2.839		0.212
	Straight	4.69E − 05	10.125		0.060