Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Figure 2

Formulation of epothilone D drug-loaded, stabilized micelles with triblock copolymers. The general formulation method includes formation of a polymer drug emulsion under high shear conditions, stabilization by iron-hydroxamate or disulfide bond formation, and lyophilization.