Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Figure 3

Mechanism of drug payload release from the polymer micelle formulations. (a) Stabilization by iron-hydroxamate bonds between polymer chains is reversed by a decrease in pH. (b) Stabilization by disulfide bonds between polymer chains is reversed by intracellular reducing agents.

(a)

(b)