Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Figure 7

Plasma pharmacokinetics from the pilot toxicokinetic dose range-finding screen of IT-147. Plasma samples were isolated and assayed for epothilone D content during the pilot toxicokinetic screen to support full toxicokinetic and pharmacokinetic studies. IT-147 demonstrated superior pharmacokinetics compared to free drug at 20 mg/kg, and a linear increase in and AUC in dosing from 20 to 40 mg/kg.