Table 3: Dosing summary for rat pharmacokinetic studies. Epothilone D free drug was dosed at 10 and 20 mg/kg. IT-147 was dosed at 10, 20, 30, and 40 mg/kg epothilone D equivalent or 500, 1000, 1500, and 2000 mg/kg formulation, respectively.

Test articleDose epothilone D (mg/kg)Dose IT-147
(mg/kg)
Epothilone D concentration
(mg/mL)
IT-147 concentration
(mg/mL)
Test article volume
(mL)

Epo D1001.1502
Epo D2002.302
IT-147105001.1557.52
IT-1472010002.301152
IT-1473015003.451732
IT-1474020004.602302