Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Table 3

Dosing summary for rat pharmacokinetic studies. Epothilone D free drug was dosed at 10 and 20 mg/kg. IT-147 was dosed at 10, 20, 30, and 40 mg/kg epothilone D equivalent or 500, 1000, 1500, and 2000 mg/kg formulation, respectively.

Test article	Dose epothilone D (mg/kg)	Dose IT-147; (mg/kg)	Epothilone D concentration; (mg/mL)	IT-147 concentration; (mg/mL)	Test article volume; (mL)
Epo D	10	0	1.15	0	2
Epo D	20	0	2.3	0	2
IT-147	10	500	1.15	57.5	2
IT-147	20	1000	2.30	115	2
IT-147	30	1500	3.45	173	2
IT-147	40	2000	4.60	230	2