Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s

Table 11

Kinetic modeling of drug release.

Parameter	Kinetic model
	Zero-order	First-order	Higuchi	Hixson-Crowell	Korsmeyer-Peppas	Weibull
Sum of residuals	1314.416	346.8983	205.599	336.2533	75.4920	258.9369
Correlation coefficient ()	0.9781	0.9821	0.9905	0.9877	0.9960	0.9860
square ()	0.8595	0.9629	0.9780	0.9635	0.9918	0.9719
	109.534	28.9081	17.1332	28.0211	6.8629	25.8936

Model fitting results revealed that the Korsmeyer-Peppas model was best fitted to the release kinetics (, highest, , lowest). Higuchi model was also close to the Korsmeyer-Peppas model. Hence test was performed for both models. It revealed significant difference between two models. Hence Korsmeyer-Peppas model was finally selected as best fitted model. Release exponent was found to be 0.580, indicating that the drug was released from the formulation by anomalous (non-Fickian) mechanism.