Table 11: Kinetic modeling of drug release.

ParameterKinetic model
Zero-orderFirst-orderHiguchiHixson-CrowellKorsmeyer-PeppasWeibull

Sum of residuals1314.416346.8983205.599336.253375.4920258.9369
Correlation coefficient ()0.97810.98210.99050.98770.99600.9860
square ()0.85950.96290.97800.96350.99180.9719
109.53428.908117.133228.02116.862925.8936

Model fitting results revealed that the Korsmeyer-Peppas model was best fitted to the release kinetics (, highest, , lowest). Higuchi model was also close to the Korsmeyer-Peppas model. Hence test was performed for both models. It revealed significant difference between two models. Hence Korsmeyer-Peppas model was finally selected as best fitted model. Release exponent was found to be 0.580, indicating that the drug was released from the formulation by anomalous (non-Fickian) mechanism.