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Journal of Drug Delivery
Volume 2016, Article ID 9324567, 8 pages
http://dx.doi.org/10.1155/2016/9324567
Research Article

Etodolac Containing Topical Niosomal Gel: Formulation Development and Evaluation

Department of Pharmaceutics, M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India

Received 30 March 2016; Accepted 12 June 2016

Academic Editor: Philippe Maincent

Copyright © 2016 Gyati Shilakari Asthana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table 1 displayed the in vitro drug release profile of the various niosomal formulations containing Etodolac. In vitro drug release from niosomal formulation was reported within the range of 61.31% to 94.91%. The highest drug release was found with Niosomal formulation (N2) at cholesterol: surfactant (1:1) ratio.

Table 2 shows the percent edema inhibition of various formulations including Niosomes, plain topical gel and topical niosomal gel containing Etodolac. The results revealed that the topical niosomal gel of Etodolac displayed maximum (53.07%) percent of edema inhibition compared to other formulations.

  1. Supplementary Material