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Journal of Drug Delivery
Volume 2017, Article ID 1892725, 6 pages
https://doi.org/10.1155/2017/1892725
Research Article

Deposition Dosages of Three Cromolyn Forms by Cascade Impactor

1Murayama Pediatrics, 3-2-33 Nagayoshi-Nagahara-Higashi, Hirano-ku, Osaka-shi 547-0013, Japan
2Omron Healthcare, Co., Ltd., 53 Kunotsubo, Terado-cho, Hyuga-shi, Kyoto 617-0002, Japan
3Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki 852-8523, Japan
4Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, 3-7-1 Habikino, Habikino-shi, Osaka 583-8588, Japan

Correspondence should be addressed to Norihide Murayama; pj.oc.oohay@99edihiron

Received 30 December 2016; Revised 26 February 2017; Accepted 6 March 2017; Published 2 April 2017

Academic Editor: Ambikanandan Misra

Copyright © 2017 Norihide Murayama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Among inhaled asthma therapies, the present study aimed to identify factors for selecting the type of inhalation therapy for asthma. Three methods are used to deliver inhaled cromoglycate, and the airway deposition rate was evaluated using a cascade impactor with 3 dosage forms: dry powder (DP), pressurized metered dose inhaler (pMDI), and solution (jet- and mesh-types). The percentage of particles with diameters of 2–6 μm was 17.0% for the capsule, 51.8% for pMDI, 49.0% for jet-type NE-C28, and 40.4% for mesh-type NE-U22. The amounts of drug deposited in the bronchi were based on the particle distribution of the various dosage forms: 3.4 mg for the capsule, 1.0 mg for pMDI, 9.8 mg for one solution (jet-type NE-C28), and 8.1 mg for the other solution (mesh-type NE-U22). Jet-type or mesh-type electric nebulizers delivered 2-3 times more of the drug than capsules, and, compared with pMDI, 8-9 times more of the drug was deposited in the bronchi/bronchioles. Electric nebulizers are considered the best method. This study suggests that the size of particles deposited at sites of obstruction is larger than previously reported, and no obstruction of small airways occurs (<2 mm).