In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice

Figure 1

In vitro siLRP2 knockdown leads to reduction of mRNA expression in renal S1 proximal tubule cells. (a) All four commercially available siRNA molecules targeting LRP2 reduced mRNA expression, individually and as a pool. siRNA #4 led to the strongest knockdown, reducing mRNA expression to 16.6 ± 1.0%   . (b) In vivo siLRP2 led to significant knockdown in mS1PT cells as well 15.6 ± 0.9%  . as compared to the scrambled control.

(a)

(b)