In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice

Figure 4

LRP2 renal expression knockdown is not dependent upon administration site. (a) Significant knockdown was appreciated in mice receiving siLRP2 through the internal jugular vein or the tail vein at 3 h ( control, internal jugular (IJ), and tail vein (TV)). Control mice include those receiving vehicle by internal jugular or tail vein injection. (b) For mice receiving siLRP2 through the internal jugular vein, no difference was noted between those receiving direct IJ injections ( = 3 control and siLRP2) and those receiving siRNA through an IJ catheter ( = 7 control, and siLRP2). as compared to the control (Ctrl).

(a)

(b)