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Journal of Drug Delivery
Volume 2017, Article ID 4759839, 12 pages
Research Article

Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery

1Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, USA
2Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, CA, USA
3California NanoSystems Institute, University of California, Los Angeles, CA, USA
4Regenerative Bioengineering and Repair Laboratory, Department of Surgery, University of California, Los Angeles, CA, USA

Correspondence should be addressed to Varghese John; ude.alcu.tendem@nhojv

Received 6 January 2017; Accepted 13 March 2017; Published 5 April 2017

Academic Editor: A. Fadda

Copyright © 2017 Naren Subbiah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. AF647-Zol in skin and femur. The AF647-Zol signal is shown in calvarial skin from a non-treated control (A) and 3 mice each receiving drug by DNV (B), NV (C), or aqueous solution (D). In 2 of 3 mice, the signal is lowest for DNVs as compared to other groups (excluding control). Signal from femur reflects distribution beyond the target tissue (skull under the application site). A femur from an untreated mouse (E) and from mice treated by DNV (F), NV (G), and aqueous solution (H) reveal slightly greater signal intensity in femur heads in G and H as compared to F.

Supplementary Figure 2. AF647-Zol signal in transected skin and bone. The AF647-Zol signal in cryosectioned bone and overlying dermis imaged by confocal microscopy from mice receiving drug via DNVs (A), NVs (B), and by aqueous solution (C) is shown, revealing great mouse-to-mouse variability.

Supplementary Figure 3. Cross-section of calvarial bone. In confocal representative images of cryosectioned calvarial (skull) bone, the signal for AF647-Zol was not apparent in mice treatment by aqueous solution (A), but some surface signal could be seen with NV delivery (B), the greatest signal was seen with DNV delivery (C).

  1. Supplementary Material