Preparation, Characterization, and In Vivo Pharmacoscintigraphy Evaluation of an Intestinal Release Delivery System of Prussian Blue for Decorporation of Cesium and Thallium
Table 2
Comparison of results of the fit to various release models.
Release models
A
B
C
D
Zero order
0.042 0.007
0.042 ± 0.004
0.047 ± 0.004
0.051 ± 0.005
0.863 ± 0.103
0.842 ± 0.102
0.947 ± 0.019
0.951 ± 0.028
First order
0.22 ± 0.095
0.163 ± 0.058
0.126 ± 0.047
0.126 ± 0.041
0.971 ± 0.040
0.949 ± 0.041
0.995 ± 0.001
0.974 ± 0.023
Higuchi
0.318 ± 0.03
0.294 ± 0.028
0.309 ± 0.030
0.345 ± 0.033
0.9502 ± 0.02595
0.902 ± 0.083
0.974 ± 0.007
0.993 ± 0.001
Hixson-Crowell
0.299 ± 0.121
0.249 ± 0.062
0.218 ± 0.056
0.220 ± 0.051
0.998 ± 0.007
0.997 ± 0.043
0.993 ± 0.006
0.991 ± 0.009
Weibull Equation
1.687 ± 0.271
1.755 ± 0.216
1.970 ± 0.159
2.379 ± 0.300
Td
8.955 ± 0.027
9.529 ± 0.216
13.417 ± 0.159
14.356 ± 0.300
0.985 ± 0.006
0.985 ± 0.024
0.979 ± 0.024
0.979 ± 0.015
Korsmeyer-Peppas
0.16 ± 0.057
0.047 ± 0.031
0.009 ± 0.047
0.003 ± 0.048
0.994 ± 0.007
0.959 ± 0.042
0.968 ± 0.021
0.965 ± 0.021
1.082 ± 0.024
1.111 ± 0.044
1.667 ± 0.358
2.133 ± 0.395
, release rate constants; , correlation coefficient; , exponent release; Td, lag time measured as a result of the dissolution process; , shape parameter of formulation.
