Journal of Drug Delivery / 2017 / Article / Tab 2

Research Article

Preparation, Characterization, and In Vivo Pharmacoscintigraphy Evaluation of an Intestinal Release Delivery System of Prussian Blue for Decorporation of Cesium and Thallium

Table 2

Comparison of results of the fit to various release models.

Release modelsABCD

Zero order0.042 0.0070.042 ± 0.0040.047 ± 0.0040.051 ± 0.005
0.863 ± 0.1030.842 ± 0.1020.947 ± 0.0190.951 ± 0.028

First order0.22 ± 0.0950.163 ± 0.0580.126 ± 0.0470.126 ± 0.041
0.971 ± 0.0400.949 ± 0.0410.995 ± 0.0010.974 ± 0.023

Higuchi0.318 ± 0.030.294 ± 0.0280.309 ± 0.0300.345 ± 0.033
0.9502 ± 0.025950.902 ± 0.0830.974 ± 0.0070.993 ± 0.001

Hixson-Crowell0.299 ± 0.1210.249 ± 0.0620.218 ± 0.0560.220 ± 0.051
0.998 ± 0.0070.997 ± 0.0430.993 ± 0.0060.991 ± 0.009

Weibull Equation1.687 ± 0.2711.755 ± 0.2161.970 ± 0.1592.379 ± 0.300
Td8.955 ± 0.0279.529 ± 0.21613.417 ± 0.15914.356 ± 0.300
0.985 ± 0.0060.985 ± 0.0240.979 ± 0.0240.979 ± 0.015

Korsmeyer-Peppas0.16 ± 0.0570.047 ± 0.0310.009 ± 0.0470.003 ± 0.048
0.994 ± 0.0070.959 ± 0.0420.968 ± 0.0210.965 ± 0.021
1.082 ± 0.0241.111 ± 0.0441.667 ± 0.3582.133 ± 0.395

, release rate constants; , correlation coefficient; , exponent release; Td, lag time measured as a result of the dissolution process; , shape parameter of formulation.

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