Table 1: Melanoma cancer formulations summarized.

PolymerAntineoplastic agents/action Cancer Route of administrationReference

MPEG-b-(PCL-ran-PLLA) diblock copolymer (MCL)5-FluorouracilMelanoma in vivo mice model tumorSubcutaneously injected drug delivery system Seo and coworkers [33]

Hydroxypropyl-β-cyclodextrin supported in in-situ-forming hydrogels with poloxamers 407 and 188Curcumin/antioxidant, anti-inflammatory, antiproliferative and antiangiogenic activitiesIn vitro
melanoma model in cell lines
Transdermal drug delivery system Sun and coworkers [34]

Pluronic F127Ibuprofen/nonsteroidal anti-inflammatoryIn vitro
melanoma model in cell lines
Topical/transdermal drug delivery system Marques and MacNeil [35]

Hydrazone cross-linked sericin/dextranDoxorubicinIn vivo melanoma model in male miceSubcutaneously injected drug delivery system Liu and coworkers [36]

Glycol chitosan benzaldehyde capped poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (GC-OHC-PEO-PPO-PEO-CHO)Paclitaxel and doxorubicin
(combination therapy)
In vivo melanoma model in male miceSubcutaneously injected drug delivery system Zhao and coworkers [37]

Poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA))Ni(II) complex with oxaprozin/antiproliferative activityIn vitro melanoma cancer cell linesTopical/transdermal drug delivery system Babić and Coworkers [38]

Nanohydrogels (NHs) based on cholesterol-graft-hyaluronic acidBovine serum amine oxidase (BSAO)In vitro melanoma cancer cell linesTopical drug delivery systemMontanari and coworkers [39]

Arginate/chitosanBovine serum amine oxidase (BSAO)Topical drug delivery systemAgostinelli and coworkers [40]

Pluronic F127AuNPs and DOXIn vivo melanoma model in male mouseSubcutaneously injected drug delivery system/hyperthermia therapy Li and coworkers [41]