Research Article
Formulation, Characterization, and In Vitro Evaluation of Transdermal Patches for Inhibiting Crystallization of Mefenamic Acid
Table 1
The composition of mefenamic acid matrix patches.
| | Formulas | Drug : PVP | Ethyl
cellulose
(g) | Diethyl
phthalate
(g) | Ethyl
acetate
(mL) | Mefenamic
acid
(g) | PVP K30
(g) | PVP K90
(g) | Ethanol
(mL) | Thickness
| Weight
|
| | BM1 | — | 1.50 | 0.45 | 40.00 | 0.38 | — | — | — | | | | BM2 | 1 : 2 | 1.50 | 0.68 | 40.00 | 0.38 | 0.76 | — | 10.00 | | | | BM3 | 1 : 2.5 | 1.50 | 0.74 | 40.00 | 0.38 | 0.95 | — | 10.00 | | | | BM4 | 1 : 1.5 | 1.50 | 0.62 | 40.00 | 0.38 | — | 0.57 | 10.00 | | | | BM5 | 1 : 2 | 1.50 | 0.68 | 40.00 | 0.38 | — | 0.76 | 10.00 | | |
|
|
at five different positions on the patches.
|
