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Journal of Drug Delivery
Volume 2017, Article ID 8284025, 10 pages
https://doi.org/10.1155/2017/8284025
Research Article

In Vitro Evaluation of Cocoa Pod Husk Pectin as a Carrier for Chronodelivery of Hydrocortisone Intended for Adrenal Insufficiency

1Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
2School of Pharmacy, University of Ghana, Legon, Ghana
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
4Central Laboratory, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana

Correspondence should be addressed to Kwabena Ofori-Kwakye; moc.oohay@eykawkirofok

Received 11 July 2017; Revised 22 November 2017; Accepted 27 November 2017; Published 24 December 2017

Academic Editor: Jia You Fang

Copyright © 2017 Ofosua Adi-Dako et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Sajan, T. A. Cinu, A. J. Chacko, J. Litty, and T. Jaseeda, “Chronotherapeutics and chronotherapeutic drug delivery systems,” Tropical Journal of Pharmaceutical Research, vol. 8, no. 5, pp. 467–475, 2009. View at Google Scholar · View at Scopus
  2. S.-Y. Lin and Y. Kawashima, “Current status and approaches to developing press-coated chronodelivery drug systems,” Journal of Controlled Release, vol. 157, no. 3, pp. 331–353, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Ballesta, P. F. Innominato, R. Dallmann, D. A. Rand, and F. A. Lévi, “Systems chronotherapeutics,” Pharmacological Reviews, vol. 69, no. 2, pp. 161–199, 2017. View at Publisher · View at Google Scholar · View at Scopus
  4. J. C. Wu, J. R. Kelsoe, C. Schachat et al., “Rapid and Sustained Antidepressant Response with Sleep Deprivation and Chronotherapy in Bipolar Disorder,” Biological Psychiatry, vol. 66, no. 3, pp. 298–301, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Buttgereit, D. Mehta, J. Kirwan et al., “Low-dose prednisone chronotherapy for rheumatoid arthritis: A randomised clinical trial (CAPRA-2),” Annals of the Rheumatic Diseases, vol. 72, no. 2, pp. 204–210, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. S. R. Bornstein, B. Allolio, W. Arlt et al., “Diagnosis and treatment of primary adrenal insufficiency: an endocrine society clinical practice guideline,” The Journal of Clinical Endocrinology & Metabolism, vol. 101, no. 2, pp. 364–389, 2016. View at Publisher · View at Google Scholar
  7. C. J. Elder and P. Dimitri, “Hydrocortisone for adrenal insufficiency,” ADC - Education and Practice Edition, vol. 100, no. 5, pp. 272–276, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. U. Knutsson, J. Dahlgren, C. Marcus et al., “Circadian cortisol rhythms in healthy boys and girls: Relationship with age, growth, body composition, and pubertal development,” The Journal of Clinical Endocrinology & Metabolism, vol. 82, no. 2, pp. 536–540, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Chan and M. Debono, “Replication of cortisol circadian rhythm: new advances in hydrocortisone replacement therapy,” Therapeutic Advances in Endocrinology and Metabolism, vol. 1, no. 3, pp. 129–138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Debono and R. J. Ross, “What is the best approach to tailoring hydrocortisone dose to meet patient needs in 2012?” Clinical Endocrinology, vol. 78, no. 5, pp. 659–664, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Lennernäs, S. Skrtic, and G. Johannsson, “Replacement therapy of oral hydrocortisone in adrenal insufficiency: The influence of gastrointestinal factors,” Expert Opinion on Drug Metabolism & Toxicology, vol. 4, no. 6, pp. 749–758, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. P. C. Hindmarsh and E. Charmandari, “Variation in absorption and half-life of hydrocortisone influence plasma cortisol concentrations,” Clinical Endocrinology, vol. 82, no. 4, pp. 557–561, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Johannsson, A. G. Nilsson, R. Bergthorsdottir et al., “Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation,” The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 2, pp. 473–481, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Falorni, V. Minarelli, and S. Morelli, “Therapy of adrenal insufficiency: An update,” Endocrine Journal, vol. 43, no. 3, pp. 514–528, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Johannsson, R. Bergthorsdottir, A. G. Nilsson, H. Lennernas, T. Hedner, and S. Skrtic, “Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study,” European Journal of Endocrinology, vol. 161, no. 1, pp. 119–130, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Verma, C. Vanryzin, N. Sinaii et al., “A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (ChronocortTM) vs. conventional hydrocortisone (CortefTM) in the treatment of congenital adrenal hyperplasia,” Clinical Endocrinology, vol. 72, no. 4, pp. 441–447, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. A. K. Philip and B. Philip, “Colon targeted drug delivery systems: a review on primary and novel approaches,” Oman Medical Journal, vol. 25, no. 2, pp. 79–78, 2010. View at Publisher · View at Google Scholar
  18. K. Ofori-Kwakye, J. T. Fell, H. L. Sharma, and A.-M. Smith, “Gamma scintigraphic evaluation of film-coated tablets intended for colonic or biphasic release,” International Journal of Pharmaceutics, vol. 270, no. 1-2, pp. 307–313, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Wu, Z. Chen, X. Wei, N. Sun, Y. Lu, and W. Wu, “Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: I. Characterization and mechanistic study,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 67, no. 3, pp. 707–714, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. T. W. Wong, G. Colombo, and F. Sonvico, “Pectin matrix as oral drug delivery vehicle for colon cancer treatment,” AAPS PharmSciTech, vol. 12, no. 1, pp. 201–214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Sriamornsak, “Application of pectin in oral drug delivery,” Expert Opinion on Drug Delivery, vol. 8, no. 8, pp. 1009–1023, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. M. J. Newton, B. Kaur, V. L. Indiana, and K. S. Rajesh, “Chronotherapeutic drug delivery of pectin vs guar gum, xanthan gum controlled release colon targeted directly compressed propranolol HCl matrix tablets,” SAJ Pharmacy and Pharmacology, vol. 1, no. 2, p. 201, 2014. View at Google Scholar
  23. L. C. Vriesmann, R. F. Teófilo, and C. Lúcia de Oliveira Petkowicz, “Extraction and characterization of pectin from cacao pod husks (Theobroma cacao L.) with citric acid,” LWT - Food Science and Technology, vol. 49, no. 1, pp. 108–116, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. S.-Y. Chan and W.-S. Choo, “Effect of extraction conditions on the yield and chemical properties of pectin from cocoa husks,” Food Chemistry, vol. 141, no. 4, pp. 3752–3758, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. O. Adi-Dako, K. Ofori-Kwakye, S. Frimpong Manso, M. E. Boakye-Gyasi, C. Sasu, and M. Pobee, “Physicochemical and antimicrobial properties of cocoa pod husk pectin intended as a versatile pharmaceutical excipient and nutraceutical,” Journal of Pharmaceutics, vol. 2016, Article ID 7608693, 12 pages, 2016. View at Publisher · View at Google Scholar
  26. O. Adi-Dako, S. Oppong Bekoe, K. Ofori-Kwakye, E. Appiah, and P. Peprah, “Novel HPLC analysis of hydrocortisone in conventional and controlled-release pharmaceutical preparations,” Journal of Pharmaceutics, vol. 2017, Article ID 9495732, 8 pages, 2017. View at Publisher · View at Google Scholar
  27. A. Gazzaniga, L. Palugan, A. Foppoli, and M. E. Sangalli, “Oral pulsatile delivery systems based on swellable hydrophilic polymers,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 68, no. 1, pp. 11–18, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Akhgari, F. Sadeghi, and H. A. Garekani, “Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets,” International Journal of Pharmaceutics, vol. 320, no. 1-2, pp. 137–142, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. United States Pharmacopoeia and National Formulary, United States Pharmacopoeia XXIII, USP Convention, Rockvillem Md, USA, 2013.
  30. R. K. Verma and S. Garg, “Selection of excipients for extended release formulations of glipizide through drug-excipient compatibility testing,” Journal of Pharmaceutical and Biomedical Analysis, vol. 38, no. 4, pp. 633–644, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. A. D. Boul, J. W. Blunt, J. W. Browne et al., “Microbiological hydroxylation of steroids. Part II. Structural information and infrared spectrometry: Carbonyl, perturbed methylene, and hydroxy-vibrations of steroidal ketones and alcohols,” Journal of the Chemical Society C: Organic, pp. 1130–1136, 1971. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Seslija, D. Veljovic, M. Kalagasidis Krusic, J. Stevanovic, S. Velickovic, and I. Popovic, “Cross-linking of highly methoxylated pectin with copper: The specific anion influence,” New Journal of Chemistry, vol. 40, no. 2, pp. 1618–1625, 2016. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Dobringer, E. R. Katzennellenbogan, and R. N. Jones, Infrared Absorption Spectra of Steroids, vol. 1, Interscience, New York, NY, USA, 1953.
  34. British Pharmacopoeia, British Pharmacopoeia Commission, Her Majesty's Stationery Office, London, UK, 2013.
  35. X. Wei, N. Sun, B. Wu, C. Yin, and W. Wu, “Sigmoidal release of indomethacin from pectin matrix tablets: effect of in situ crosslinking by calcium cations,” International Journal of Pharmaceutics, vol. 318, no. 1-2, pp. 132–138, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. B. N. Singh, “Modified-release solid formulations for colonic delivery,” Recent Patents on Drug Delivery & Formulation, vol. 1, no. 1, pp. 53–63, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Sreelatha and C. K. Brahma, “Colon targeted drug delivery—a review on primary and novel approaches,” Journal of Global Trends in Pharmaceutical Sciences, vol. 4, no. 3, pp. 1174–1183, 2013. View at Google Scholar
  38. S. Spireas and S. M. Bolton, “Liquisolid systems and methods of preparing same,” US Patent 6,096,337, 2000.
  39. J. T. McConville, A. C. Ross, A. R. Chambers, G. Smith, A. J. Florence, and H. N. E. Stevens, “The effect of wet granulation on the erosion behaviour of an HPMC-lactose tablet, used as a rate-controlling component in a pulsatile drug delivery capsule formulation,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 57, no. 3, pp. 541–549, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. T. H. Nguyen, W. Shen, and K. Hapgood, “Effect of formulation hydrophobicity on drug distribution in wet granulation,” Chemical Engineering Journal, vol. 164, no. 2-3, pp. 330–339, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Nykänen, S. Lempää, M.-L. Aaltonen, H. Jürjenson, P. Veski, and M. Marvola, “Citric acid as excipient in multiple-unit enteric-coated tablets for targeting drugs on the colon,” International Journal of Pharmaceutics, vol. 229, no. 1-2, pp. 155–162, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. L. D. Bruce, N. H. Shah, A. Waseem Malick, M. H. Infeld, and J. W. McGinity, “Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 59, no. 1, pp. 85–97, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. L.-F. Fan, W. He, M. Bai et al., “Biphasic drug release: Permeability and swelling of pectin/ethylcellulose films, and in vitro and in vivo correlation of film-coated pellets in dogs,” Chemical & Pharmaceutical Bulletin, vol. 56, no. 8, pp. 1118–1125, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. A. V. Singh, “Biopolymers in drug delivery: a review,” Pharmacology Online Newsletters, vol. 1, pp. 666–674, 2011. View at Google Scholar
  45. P. S. Chaudhari and P. Shanmugasundaram, “Modification & characterization of natural polymer for development of dosage forms,” International Journal of PharmTech Research, vol. 6, no. 3, pp. 1131–1142, 2014. View at Google Scholar · View at Scopus
  46. M. Qi, P. Wang, and D. Wu, “A novel pH- and time-dependent system for colonic drug delivery,” Drug Development and Industrial Pharmacy, vol. 29, no. 6, pp. 661–667, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. M. E. Sangalli, A. Maroni, L. Zema, C. Busetti, F. Giordano, and A. Gazzaniga, “In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery,” Journal of Controlled Release, vol. 73, no. 1, pp. 103–110, 2001. View at Publisher · View at Google Scholar · View at Scopus
  48. Q.-R. Cao, H.-G. Choi, D.-C. Kim, and B.-J. Lee, “Release behavior and photo-image of nifedipine tablet coated with high viscosity grade hydroxypropylmethylcellulose: Effect of coating conditions,” International Journal of Pharmaceutics, vol. 274, no. 1-2, pp. 107–117, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. P. Costa and J. M. Sousa Lobo, “Modeling and comparison of dissolution profiles,” European Journal of Pharmaceutical Sciences, vol. 13, no. 2, pp. 123–133, 2001. View at Publisher · View at Google Scholar · View at Scopus
  50. R. W. Korsmeyer, R. Gurny, E. Doelker, P. Buri, and N. A. Peppas, “Mechanisms of solute release from porous hydrophilic polymers,” International Journal of Pharmaceutics, vol. 15, no. 1, pp. 25–35, 1983. View at Publisher · View at Google Scholar · View at Scopus