Research Article

In Vitro Evaluation of Cocoa Pod Husk Pectin as a Carrier for Chronodelivery of Hydrocortisone Intended for Adrenal Insufficiency

Table 1

Formulation details of CPH pectin-based hydrocortisone matrix tablet formulations (~300 mg).

Code Formulation techniqueHydrocortisone (mg)CPH pectin (mg)Microcrystalline cellulose (mg)Dicalcium phosphate dihydrate (mg)Magnesium stearate (mg)Sodium starch glycolate (mg)

F1Direct compression-
F2Direct compression-
F3Direct compression-
F4Wet granulation--
F5Wet granulation--

a: hot water soluble pectin (HWSP); b: citric acid soluble pectin (CASP).