Evaluation of Chitosan-Microcrystalline Cellulose Blends as Direct Compression Excipients

Table 1

Tablet formula.

Ingredient/tablet	F1	F2	F3	F4	F5	F6	F7	F8	F9
Metronidazole (mg)	200.0	200.0	200.0	200.0	200.0	200.0	200.0	200.0	200.0
MCC (mg)	300.0	270.0	240.0	200.0	150.0	270.0	240.0	200.0	150.0
Chitosan (mg)	0.0	30.0	60.0	100.0	150.0	0.0	0.0	0.0	0.0
Lactose (mg)	0.0	0.0	0.0	0.0	0.0	30.0	60.0	100.0	150.0
Mg stearate (mg)	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5
Talc (mg)	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5
Tablet weight (mg)	505.0	505.0	505.0	505.0	505.0	505.0	505.0	505.0	505.0

MCC: microcrystalline cellulose.