Evaluation of Chitosan-Microcrystalline Cellulose Blends as Direct Compression Excipients

Table 2

Some physicochemical properties of chitosan, lactose, and microcrystalline cellulose.

Parameters	Chitosan	Lactose	Microcrystalline cellulose
Moisture content (%)	7.66 ± 0.98	2.00 ± 0.47	1.00 ± 0.00
Moisture sorption capacity (%)	1.33 ± 0.05	0.36 ± 0.04	0.21 ± 0.01
Bulk density (g/cm^3)	0.60 ± 0.01	0.51 ± 0.01	0.32 ± 0.00
Tapped density (g/cm^3)	0.74 ± 0.01	0.77 ± 0.00	0.44 ± 0.01
True density (g/cm^3)	1.74	1.45	1.45
Carr’s index (%)	18.90	33.90	28.20
Hausner’s ratio	1.23	1.51	1.39
Hydration capacity	0.60 ± 0.01	0.05 ± 0.01	2.23 ± 0.02
Swelling capacity (%)	14.29 ± 0.00	Dissolved completely	39.78 ± 1.55