Advanced Lipid Technologies® (ALT®): A Proven Formulation Platform to Enhance the Bioavailability of Lipophilic Compounds

Figure 6

SC411 significantly increases DHA levels in red blood cell (RBC) membranes in a model of Sickle Cell Disease (SCD). Wild type (WT) and Townes, a recognized animal model of SCD, mice with a deficiency in DHA were treated with SC411 (50 mg DHA/Kg/day + ALT®) for 42 days before measuring the RBC membrane levels of DHA. (a) The SCD mice (red) have significantly lower levels of DHA as compared with WT (blue) at baseline. SC411-treated SCD mice (dark red) restore the RBC membrane DHA levels to WT levels. (b) Similarly, the DHA/AA ratio in RBC membranes is also low in SCD mice (red) as compared with WT (blue) at baseline and SC411-treated SCD mice (dark red) significantly increase DHA/AA ratio in RBC membranes.

(a)

(b)