Table of Contents
Journal of Hormones
Volume 2013, Article ID 294534, 4 pages
Research Article

Estradiol Solubility in Aqueous Systems: Effect of Ionic Concentrations, pH, and Organic Solvents

1Department of Medicine, Massachusetts General Hospital, MGH Clinical Laboratory Research Core, Boston, MA 02114, USA
2Framingham State University, Framingham, MA 01710, USA

Received 25 March 2013; Accepted 23 June 2013

Academic Editor: Hirotaka Sakamoto

Copyright © 2013 John E. A. Carter and Patrick M. Sluss. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. J. Reed, P. A. Beranek, and V. H. T. James, “Oestrogen production and metabolism in peri-menopausal women,” Maturitas, vol. 8, no. 1, pp. 29–34, 1986. View at Google Scholar · View at Scopus
  2. W. Rosner, S. E. Hankinson, P. M. Sluss, H. W. Vesper, and M. E. Wierman, “Chanllenges to the measurement of estradiol: an endocrine society position statement,” Journal of Clinical Endocrinology & Metabolism, vol. 98, pp. 1376–1387, 2013. View at Google Scholar
  3. P. M. Sluss, F. J. Hayes, J. M. Adams et al., “Mass spectrometric and physiological validation of a sensitive, automated, direct immunoassay for serum estradiol using the Architect,” Clinica Chimica Acta, vol. 388, no. 1-2, pp. 99–105, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. Estradiol Elisa Kit Instructions Product #70A,
  5. R. J. Lewis, Hawley’s Condensed Chemical Dictionary, Van Nostrand Reinhold, New York, NY, USA, 13th edition, 1997.
  6. E. G. Salole, “Estradiol,” Analytical Profiles of Drug Substances and Excipients, vol. 15, pp. 283–318, 1986. View at Publisher · View at Google Scholar · View at Scopus
  7. S. R. Cummings, T. Duong, E. Kenyon, J. A. Cauley, M. Whitehead, and K. A. Krueger, “Serum estradiol level and risk of breast cancer during treatment with raloxifene,” Journal of the American Medical Association, vol. 287, no. 2, pp. 216–220, 2002. View at Google Scholar · View at Scopus
  8. D. B. Dubal, M. E. Wilson, and P. M. Wise, “Estradiol: a protective and trophic factor in the brain,” Journal of Alzheimer's Disease, vol. 1, no. 4-5, pp. 265–274, 1999. View at Google Scholar · View at Scopus
  9. D. M. Henricks, S. L. Gray, J. J. Owenby, and B. R. Lackey, “Residues from anabolic preparations after good veterinary practice,” APMIS, vol. 109, no. 4, pp. 273–283, 2001. View at Google Scholar · View at Scopus
  10. T. A. Ternes, H. Andersen, D. Gilberg, and M. Bonerz, “Determination of estrogens in sludge and sediments by liquid extraction and GC/MS/MS,” Analytical Chemistry, vol. 74, no. 14, pp. 3498–3504, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Doisy, C. D. Veler, and S. Thayer, “Folliculin from urine of pregnant women,” American Journal of Physiology, vol. 90, pp. 329–330, 2002. View at Google Scholar
  12. L. Siekmann, “Determination of oestradiol-17 beta in human serum by isotope dilution-mass spectrometry. Definitive methods in clinical chemistry, II,” Journal of Clinical Chemistry and Clinical Biochemistry, vol. 22, no. 8, pp. 551–557, 1984. View at Google Scholar · View at Scopus
  13. H. Wu, C. Ramsay, P. Ozaeta, L. Liu, and H. Aboleneen, “Serum estradiol quantified by isotope dilution-gas chromatography/mass spectrometry,” Clinical Chemistry, vol. 48, no. 2, pp. 364–366, 2002. View at Google Scholar · View at Scopus
  14. X. Xiao and D. McCalley, “Quantitative analysis of estrogens in human urine using gas chromatography/negative chemical ionization mass spectrometry,” Rapid Communications in Mass Spectrometry, vol. 14, pp. 1991–2001, 2000. View at Google Scholar
  15. M. H. Choi, K. R. Kim, and B. C. Chung, “Determination of estrone and 17β-estradiol in human hair by gas chromatography-mass spectrometry,” Analyst, vol. 125, no. 4, pp. 711–714, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. H.-B. Lee and T. E. Peart, “Determination of 17 beta-estradiol and its metabolites in sewage effluent by solid phase extraction and gas chromatography/mass spectrometry,” Journal of AOAC International, vol. 81, no. 6, pp. 1209–1216, 1998. View at Google Scholar · View at Scopus
  17. S. J. Gaskell, E. M. H. Finlay, and A. W. Pike, “Analyses of steroids in saliva using highly selective mass spectrometric techniques,” Biomedical Mass Spectrometry, vol. 7, no. 11-12, pp. 500–504, 1980. View at Google Scholar · View at Scopus
  18. L. M. Thienpont, P. G. Verhaeghe, K. A. Van Brussel, and A. P. De Leenheer, “Estradiol-17β quantified in serum by isotope dilution-gas chromatography-mass spectrometry: reversed-phase C18 high-performance liquid chromatography compared with immuno-affinity chromatography for sample pretreatment,” Clinical Chemistry, vol. 34, no. 10, pp. 2066–2069, 1988. View at Google Scholar · View at Scopus
  19. L. Dehennin, “Estradiol-17β determined in plasma by gas chromatography-mass spectrometry with selected ion monitoring of mixed silyl ether-perfluoroacyl ester derivatives and use of variable stable-isotope-labeled internal standards,” Clinical Chemistry, vol. 35, no. 4, pp. 532–536, 1989. View at Google Scholar · View at Scopus
  20. M. Dowsett, P. E. Goss, T. J. Powles et al., “Use of the aromatase inhibitor 4-hydroxyandrostenedione postmenopausal breast cancer: optimization of therapeutic dose and route,” Cancer Research, vol. 47, no. 7, pp. 1957–1961, 1987. View at Google Scholar · View at Scopus
  21. K. Carlström, “Low endogenous estrogen levels—analytical problems and tissue sensitivity,” Acta Obstetricia et Gynecologica Scandinavica, Supplement, vol. 75, no. 163, pp. 11–15, 1996. View at Google Scholar · View at Scopus
  22. T. Yasui, M. Yamada, H. Kinoshita et al., “Combination of automatic HPLC-RIA method for determination of estrone and estradiol in serum,” Journal of Clinical Laboratory Analysis, vol. 13, pp. 266–272, 1999. View at Google Scholar
  23. B. G. England, G. H. Parsons, R. M. Possley, D. S. McConnell, and A. R. Midgley, “Ultrasensitive semiautomated chemiluminescent immunoassay for estradiol,” Clinical Chemistry, vol. 48, no. 9, pp. 1584–1586, 2002. View at Google Scholar · View at Scopus
  24. T. Vega-Morales, R. Guedes-Alonso, Z. Sosa-Ferrera, and J. J. Santa-Rodrigues, “Determination and assessment of estradiol-mimicking compounds in the dissolved and particulate phases of wastewater treatment plant samples,” Journal of AOAC International, vol. 95, pp. 1195–1204, 2012. View at Google Scholar