Table of Contents
Journal of Hormones
Volume 2016, Article ID 6923239, 7 pages
Research Article

Involvement of Ovarian Estradiol Biosynthesis and Pituitary FSH Expression in the Mechanism of Human Chorionic Gonadotropin Stimulation of Uterine Growth in Immature Female Rats

1INRA, CNRS, Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France
2Tours University, 37200 Tours, France

Received 25 November 2015; Revised 21 January 2016; Accepted 26 January 2016

Academic Editor: Christos Stournaras

Copyright © 2016 Sandrine Rafert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In a previous work, we showed that human Chorionic Gonadotropin (hCG) alone is able to stimulate uterine ponderal growth in immature female rats. In the present paper, we provide new information indicating that a single 100 ng hCG injection increased ovarian androgen availability and aromatase activity. These changes are consistent with an increase in ovarian estradiol secretion. Ovarian activin βA and activin βB subunit RNAs expression were also increased following hCG injection. Most interestingly, this treatment also led to an increase in FSHβ subunit mRNA expression in the pituitary, which might be due to hCG-stimulated ovarian activin secretion. We have not been able so far to follow the kinetics of the plasma concentrations of activin and FSH in hCG-treated animals compared to control animals. This has to be explored in the future to provide a more complete assessment of our model.