Table of Contents
Journal of Medical Engineering
Volume 2013 (2013), Article ID 412802, 4 pages
Research Article

Applying the Bispectral Analysis on Widespread Diffuse Cross-Frequency Interactive Effects

1Graduate Institute of Science Education, National Kaohsiung Normal University, Kaohsiung 824, Taiwan
2Department of Physics, National Kaohsiung Normal University, Kaohsiung 824, Taiwan

Received 15 September 2013; Accepted 18 October 2013

Academic Editor: Norio Iriguchi

Copyright © 2013 Chia-Ju Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this paper is applying the bispectral analysis on widespread diffuse cross-frequency interactive effects. The event-related potentials (ERPs) research method was used in this study and it could collect the widespread diffuse cross-frequency from mild cognitive impairment (MCI) patients’ brain wave. In this study, the brain wave data were collected from 12 MCI subjects, 12 healthy elderly, and 12 healthy young. The findings showed that the decreased interhemispheric coherence of 8.8 Hz for MCI compared with healthy elderly in the central-parietal cortex to respective surrounding sites and each MCI subject showed significantly widespread diffuse pattern of cross-frequency interactions in comparison with the healthy controls in the left central-parietal and right frontal. This study provides some explanation and suggestions for these findings.