Table of Contents
Journal of Medical Engineering
Volume 2013, Article ID 581617, 13 pages
http://dx.doi.org/10.1155/2013/581617
Research Article

A LabVIEW Platform for Preclinical Imaging Using Digital Subtraction Angiography and Micro-CT

Department of Radiology, Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA

Received 18 November 2012; Accepted 21 January 2013

Academic Editor: Eugene Fourkal

Copyright © 2013 Cristian T. Badea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

CT and digital subtraction angiography (DSA) are ubiquitous in the clinic. Their preclinical equivalents are valuable imaging methods for studying disease models and treatment. We have developed a dual source/detector X-ray imaging system that we have used for both micro-CT and DSA studies in rodents. The control of such a complex imaging system requires substantial software development for which we use the graphical language LabVIEW (National Instruments, Austin, TX, USA). This paper focuses on a LabVIEW platform that we have developed to enable anatomical and functional imaging with micro-CT and DSA. Our LabVIEW applications integrate and control all the elements of our system including a dual source/detector X-ray system, a mechanical ventilator, a physiological monitor, and a power microinjector for the vascular delivery of X-ray contrast agents. Various applications allow cardiac- and respiratory-gated acquisitions for both DSA and micro-CT studies. Our results illustrate the application of DSA for cardiopulmonary studies and vascular imaging of the liver and coronary arteries. We also show how DSA can be used for functional imaging of the kidney. Finally, the power of 4D micro-CT imaging using both prospective and retrospective gating is shown for cardiac imaging.