Table of Contents
Journal of Mycology
Volume 2014, Article ID 395041, 9 pages
Research Article

Species Diversity, Antifungal Susceptibility, and Virulence Attributes of Candida Colonising the Oral Cavities of Adult Diabetic Patients

1Department of Biosciences, Jamia Millia Islamia, New Delhi 110 025, India
2Apex Regional S T D Centre, VMMC and Safdarjung Hospital, New Delhi 110 029, India
3Department of Endocrinology, VMMC and Safdarjung Hospital, New Delhi 110 029, India
4All India Institute of Medical Sciences, New Delhi 110 029, India

Received 26 June 2014; Revised 29 August 2014; Accepted 2 September 2014; Published 18 September 2014

Academic Editor: Ángel Domínguez

Copyright © 2014 Deepa Anil Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oral candidiasis is a common occurrence in diabetic patients. Species of Candida isolated from these infections and their virulence pattern undergo changes over time and require periodic assessments. Objective of this study was to determine changes in the spectrum of Candida species colonizing oral cavity, their antifungal susceptibility patterns, and virulence attributes, in adult diabetic patients. Oral swabs were collected from 100 patients with diabetes mellitus (DM) and an equal number of healthy controls. Specimens were cultured for Candida and species were identified, according to standard protocols. Of 100 diabetic patients, 42 were colonized by yeasts with C. albicans as the predominant species (51%). Non-Candida albicans Candida (NCAC) species accounted for 47% of the specimens, with C. tropicalis being the commonest. Among healthy controls, 23 were colonized by Candida species, of which C. albicans was predominant. Results obtained indicate that C. albicans continues to be the predominant species in oral cavities of diabetic patients. Candidal carriage was significantly associated with duration of diabetes and fasting blood sugar levels. Virulence attributes, proteinase and phospholipase secretion, and biofilm formation were significantly higher in DM group.