Insights into the Structures of DNA Damaged by Hydroxyl Radical: Crystal Structures of DNA Duplexes Containing 5-Formyluracil
Figure 7
Models of the Watson-Crick-type fU:A (gray) and the reversed wobble fU:G (blue) pairs bound in DNA polymerase I (PDB-ID 3EZ5, see [30]), constructed by fitting the paired bases to the observed pair. The template residues and incoming NTP molecules are bound in the binding pocket of the enzyme, the hydrophilic residues of which may interact to the atoms at the edges of the two bases. The guanine N2 and C2 atoms of the wobble fU:G pair (red) are too close to the protein atoms.
