Review Article
Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair
Table 1
Animal models of nicotinamide or niacin effect on carcinogenesis.
| Animal | Carcinogen | Form of nicotinamide (dose) | Organ | Effect on tumor | Ref. |
| Mouse | None | Oral | All | None | [40] | Mouse | UV | Topical(200 M) | Skin | Inhibition | [52] | Mouse | UVB | Oral (niacin)(0.5%; 1% diet) | Skin | Inhibition | [53] | Mouse | TPA | Topical (150 M) | Skin | Inhibition | [54] | Mouse | DMBA and Croton oil | Oral(0.2% diet) | Skin | None | [55] | Mouse | Urethane | Oral (0.25%; 0.4% diet) Oral (niacin) (0.25% diet) | Lung | Inhibition |
[41] | Lung | None | Mouse | Urethane | Oral (1%; 2.5% diet) | Lung | Inhibition | [42] | Rat | ENU | Oral (niacin) (0.4% diet) | Bone marrow (haemopoeitic cells) | Inhibition | [43] | Rat | Bracken fern | Oral (0.5% diet) | Intestine | Inhibition |
[56] | Bladder | Inhibition | Hamster | BOB | ip (30 mg/kg bw) | Pancreas | Inhibition | [57] | Rat | DEN | ip (350–500 mg/kg bw) | Kidney | Increase |
[46] | Liver | Inhibition | Rat | DEN | Oral (0.082%; 0.37%) | Kidney | Increase | [47] | Rat | Streptozotocin | ip (350 mg/kg bw) | Pancreas | Increase | [48] | Rat | Streptozotocin | ip (350 mg/kg bw) | Kidney | Inhibition | [49] | Rat | Heliotrine | ip (500 mg/kg bw) | Pancreas | Increase | [50] | Mouse | Transplanted murine breast adenocarcinoma | Oral (2.5%; 5%) | Recipient subcutaneous tissue | Inhibition | [44] | Mouse | Transplanted murine breast adenocarcinoma | ip (1000 mg/kg bw) | Recipient subcutaneous tissue | Inhibition | [45] |
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