Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response

Table 1

IC₅₀ values for response of MSH2-deficient and MSH2-proficient cells to Reserpine analogs.

Compound	IC50 [𝜇M]				Fold difference
	MSH2-deficient	95% CL	MSH2-proficient	95% CL
cisplatin	75	46–130	47	35–64	1.6
reserpine	93	74–120	61	54–70	1.5
rescinnamine	87	53–150	39	32–47	2.6
rescinnamine + 10 𝜇M cisplatin (24 h)	12	11–13	11	10–13	1.1
rescinnamine + 10 𝜇M cisplatin (48 h)	9.1	7–12	9.7	9–11	0.94
rescinnamine + 10 𝜇M cisplatin (72 h)	9.9	9–11	9.8	5^-13–2^14	1.01
benzoyl	110	100–120	132	107–160	0.83
3-methoxy benzoyl	83	74–92	88	75–104	0.94
4-methoxy benzoyl	68	58–81	67	59–75	1.01
3,4-dimethoxy benzoyl	85	78–93	66	59–74	1.3
3,5-dimethoxy benzoyl	36	28–48	38	30–49	0.95
cinnamoyl	150	92–250	130	107–160	1.2
methylenedioxybenzoyl	36	32–41	51	45–58	0.71
deserpidine	59	51–69	48	46–51	1.2