Base Sequence Context Effects on Nucleotide Excision Repair
Figure 3
(a) In the 5′-C[G*]G sequence context, steric hinderance between the B[a]P moiety and nearby guanine amino groups causes the episodic denaturation of the C5 G20 Watson-Crick hydrogen bond. (b) In the 5′-G[G*]C sequence context, steric hindrance between the B[a]P moiety and nearby guanine amino groups causes untwisting, manifested as a bend. (c) and (d) Definition of DNA duplex helicoidal parameters Roll and Twist, respectively. These cartoons are adapted with permission from Lu et al., Nucleic Acids Res. 31 (17): 5108–5121, Figure 1, Copyright 2003, Oxford University Press.
