Research ArticleDesign, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide--Deoxyguanosine Hybrids
Scheme 2
Reaction conditions (i) 3-(Fmoc-amino)propionyl chloride (prepared from -Fmoc--alanine and SOCL2), THF/Pyridine, rt, 72 hours. (ii) 10, EDCI, DMAP, DMF, rt, 24 hours. (iii) 0.2 M TEAF, THF, rt, 30 minutes.