Research ArticleDesign, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide--Deoxyguanosine Hybrids
Scheme 4
Reaction conditions (i) 1. piperidine, DMF, rt, 20 minutes. 2. 19, Et3N, DMF, 60°C 12 hours. (ii) 0.5 M DBU, pyridine, rt, 12 hours. (iii) 0.05 M NaOMe, MeOH/pyridine, rt, 2 hours.