Journal of Nucleic Acids

Review Article

Formation, Repair, and Genotoxic Properties of Bulky DNA Adducts Formed from Tobacco-Specific Nitrosamines

Table 1

Adduct levels in NNK-treated rats [51].
TissueNNK Dose ( m m o l / k g ) a 7-pobG š‘‚ 2 -pobdT š‘‚ 2 -pobC š‘‚ 6 -pobG
M e a n Ā± S . D . , š‘ = 5 (fmol/mg DNA)
Lungsaline control N . D . b N.D.N.D.N.D.
0.025 9 3 3 Ā± 8 9 1 1 2 0 Ā± 6 6 4 8 3 Ā± 3 6 2 5 1 Ā± 2 6
0.1 1 8 0 0 Ā± 4 7 8 2 0 2 0 Ā± 4 8 3 8 4 0 Ā± 1 6 9 4 8 7 Ā± 1 0 1
Liversaline controlN.D.N.D.N.D.N.D.
0.025 3 5 5 0 Ā± 1 6 0 0 3 5 3 0 Ā± 7 2 5 2 9 3 0 Ā± 5 2 1 2 8 Ā± 1 7
0.1 1 2 2 0 0 Ā± 1 6 0 0 1 2 3 0 0 Ā± 1 6 9 0 7 8 0 0 Ā± 1 6 8 0 1 4 0 Ā± 2 5
a Administered by s.c. injection daily for 4 days.
b N.D.: not detected (detection limit, 3ā€‰fmol/mg DNA).