DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences

<table>Other DNA alkylating agents inducing local destabilization of the DNA helix. (a) Structures of some DNA alkylating molecules that destabilize the DNA helix. (b) Three-dimensional organization of the psoralen derivative <i>HMT</i> (a) and <svg height="13.45" id="M39" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 21.237499 13.45" width="21.237499" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">(</tspan>
<tspan style="font-size: 12.50px; " x="4.1634989" y="0">+</tspan>
<tspan style="font-size: 12.50px; " x="12.728054" y="0">)</tspan>
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</svg><i>-anti-BPDE</i> (b) bound to DNA (crystallographic data [mmdbId:52343<svg height="12.9125" id="M40" style="vertical-align:-1.95624pt" version="1.1" viewbox="0 0 5.3249998 12.9125" width="5.3249998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.9125)">
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</svg> [<a href="/journals/jna/2010/290935/#B117">118</a>] and [mmdbId:52106<svg height="12.9125" id="M41" style="vertical-align:-1.95624pt" version="1.1" viewbox="0 0 5.3249998 12.9125" width="5.3249998" xmlns="http://www.w3.org/2000/svg">
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</svg>, respectively, [<a href="/journals/jna/2010/290935/#B118">119</a>]).</table>

Journal of Nucleic Acids

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Figure 5

Figure 5: DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences 