Journal of Nucleic Acids / 2010 / Article / Fig 5

Review Article

DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences

Figure 5

Other DNA alkylating agents inducing local destabilization of the DNA helix. (a) Structures of some DNA alkylating molecules that destabilize the DNA helix. (b) Three-dimensional organization of the psoralen derivative HMT (a) and ( + ) -anti-BPDE (b) bound to DNA (crystallographic data [mmdbId:52343 ] [118] and [mmdbId:52106 ] , respectively, [119]).

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