Targeting the OB-Folds of Replication Protein A with Small Molecules
Figure 8
Comparison of the ssDNA-binding interface of OB-fold containing proteins. Proteins are shown as cartoon and ssDNA as stick renderings. (a) Structure of the homotetramer of EcSSB (1EYG); DNA is shown in gold [31]. (b) Structure of the RPA DBD-A/B (1JMC); DNA is shown in orange [27] (c) Structure of the human Pot1(DBD) (1XJV); DNA is shown in orange [4]. Each structure is shown in the same orientation to highlight the different ssDNA binding interfaces used by each of these proteins for their specific functions.
