BLM Deficiency Is Not Associated with Sensitivity to
Hydroxyurea-Induced Replication Stress
Figure 3
Levels of HU-induced SCEs are similar in BLM-deficient cells and control cells. (a) Number of SCEs per chromosome in HeLaV or in HeLashBLM cells transfected as in Figure 1(a), left untreated or treated with 2 mM HU for 16 h. Between 2174 and 4314 chromosomes from 5 independent experiments were analyzed for each set of conditions. Errors bars represent standard errors of the means. (b) Number of SCEs per chromosome in BS-GFP-BLM and BS-GFP cells left untreated or treated as in (a). Between 1864 and 2255 chromosomes from 4 independent experiments were analyzed for each set of conditions. Errors bars represent standard errors of the means.
