Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion

Figure 1

HR-mediated reversion of the 𝑝^un allele. Schematic of the 𝑝^un mutation (tandem duplication of exons 6–18), where an HR event mediates the deletion of one copy rendering a functional p gene allowing pigmentation of RPE cells. Circles and arrowheads represent centromere and telomere DNA, respectively.