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Journal of Nucleic Acids
Volume 2010, Article ID 426505, 14 pages
http://dx.doi.org/10.4061/2010/426505
Research Article

Effect of N3-Methyladenine and an Isosteric Stable Analogue on DNA Polymerization

1Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA
2Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA
3Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
4Molecular Mutagenesis and DNA Repair Unit, Department of Epidemiology and Prevention, National Cancer Research Institute (IST), 16132 Genova, Italy

Received 29 January 2010; Accepted 25 June 2010

Academic Editor: Ramón Eritja

Copyright © 2010 Samuel Settles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [4 citations]

The following is the list of published articles that have cited the current article.

  • Paola Monti, Christopher Broxson, Alberto Inga, Ruo-wen Wang, Paola Menichini, Silvia Tornaletti, Barry Gold, and Gilberto Fronza, “3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro,” Dna Repair, vol. 10, no. 8, pp. 861–868, 2011. View at Publisher · View at Google Scholar
  • Noel Gardner, David Magers, and Glake Hill, “Theoretical study of the pre- and post-translational effects of adenine and thymine tautomers and methyl derivatives,” Journal of Molecular Modeling, 2013. View at Publisher · View at Google Scholar
  • Paola Monti, Giorgia Foggetti, Paola Menichini, Alberto Inga, Barry Gold, and Gilberto Fronza, “Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: Clarifying the role of N3-methyladenine,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2013. View at Publisher · View at Google Scholar
  • Prema Iyer, Ajay Srinivasan, Sreelekha K. Singh, Gerard P. Mascara, Sevara Zayitova, Brian Sidone, Elise Fouquerel, David Svilar, Robert W. Sobol, Michael S. Bobola, John R. Silber, and Barry Gold, “Synthesis and Characterization of DNA Minor Groove Binding Alkylating Agents,” Chemical Research In Toxicology, vol. 26, no. 1, pp. 156–168, 2013. View at Publisher · View at Google Scholar