Journal of Nucleic Acids / 2010 / Article / Tab 2

Research Article

Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers

Table 2

Logarithm of the binding constants (log 𝐾 ) calculated from data recorded throughout fluorescence titrations using Equispec program assuming a 1 : 1 stoichiometry DNA : ligand for the interaction complex (details in materials and methods). Compounds 1–4 correspond to the acridine dimers and trimers prepared in this study. HT24, 24bcl, cmyc, and Dickerson correspond to oligonucleotide sequences shown in Table 1.


HT244.9 ± 0.44.6 ± 0.55.3 ± 0.3n.d.
24bcl6.8 ± 0.55.1 ± 0.15.3 ± 0.2n.d.
cmyc5.5 ± 0.34.9 ± 0.24.8 ± 0.55.3 ± 0.2

n.d. not determined.

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