| NER Factors | | Name | | Function | References | Human | Yeast S. cerevisiae | Size (a.a) |
| XPC-hHR23B | XPC | Rad4 | 940 | Binds damaged DNA; recruits other NER proteins; works with hHR23B. involved only in GGR | [22, 226, 227] | hHR23B | Rad23 | 409 | Stimulates XPC activity in vitro; contains ubiquitin domain | [22, 227–229] | hHR23A | Rad23 | 363 | Can substitute for hHR23B in vitro | [227, 230] | CEN2 | — | 172 | Stabilizes the XPC-hHR23B complex | [216, 231] |
| TFIIH | XPB | Rad25/SSL2 | 782 | helicase | [227, 232, 233] | XPD | Rad3 | 760 | helicase | [227, 233, 234] | p34 | TFB4 | 303 | DNA binding? | [227, 228, 235] | p44 | SSL1 | 395 | DNA binding? | [227, 228, 233] | p62 | TFB1 | 548 | Core TFIIH subunit | [227, 228, 236] | p52 | TFB2 | 462 | Core TFIIH subunit | [227, 228, 233, 236] | Mat1 | TFB3 | 309 | CDK assembly factor; CAK subcomplex | [227, 228] | Cdk7 | Kin28 | 346 | CDK, C-terminal domain kinase; (CAK) subcomplex; phosphorylates RNA pol. II and other substrates | [227, 228] | Cyclin H | CCL1 | 323 | Cyclin; CAK subcomplex | [227, 228] | TFB5/TTDA (p8) | Tfb5 | 71 | Stabilizing subunit | [228, 237] |
| XPA | XPA | Rad14 | 273 | Binds damaged DNA and facilitates repair complex assembly; affinity for ssDNA | [183, 238, 239] |
| | RPA70 | Rfa1 | 616 | Stabilizes opened DNA complex; positions nucleases; ssDNA binding | [227, 240–242] | RPA | RPA32 | Rfa2 | 270 | Stabilizes opened DNA complex; positions nucleases; ssDNA binding | [227, 240–242] | | RPA14 | Rfa3 | 121 | Stabilizes open complex (with XPA/Rad14) | [22, 240, 241] |
| XPG | XPG | Rad2 | 1186 | Endonuclease (catalyzes incision); stabilizes full open complex | [228, 243–245] |
| ERCC1-XPF | ERCC1 | Rad10 | 297 | Part of structure-specific endonuclease; catalyzes incision; interstrand cross-link repair | [227, 246–248] | XPF | Rad1 | 905 | Part of endonuclease (-incision); recombination via single-strand annealing | [227, 246, 249] |
| DDB | DDB1 | — | 1140 | CPD recognition? | [228, 250, 251] | DDB2 | — | 428 | Chromatin remodeling? | [228, 251] |
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