Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining

Figure 6

Crystal structure of DNA-PKcs. Molecular surface of the DNA-PKcs structure showing (a) front and (b) side views. Also shown in (a), is the overall size of DNA-PKcs with the potential flexible sites indicated in blue arrows. The molecule is colour coded as follows: the ring structure that is predominantly HEAT repeats is green; the forehead that is part of the ring structure is light green; the putative DNA binding domain is magenta; the larger C-terminal part that includes the FAT and FATC domains is red, and the kinase domain is yellow.