Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

<table>Meta-analysis of 10 Caucasian studies of lung cancer and the <i>ERCC2</i> Lys751Gln polymorphism (Gln/Gln versus Lys/Lys). The center of a box and the horizontal line (logarithm) indicate the odds ratio (OR) and the 95% confidence interval (CI) in each study, with the areas of the boxes representing the weight of each study. The summary OR based on random effects model is represented by the middle of a diamond whose width indicated the 95% CI. The summary OR is shown by the dotted vertical line. Statistical heterogeneity between studies was assessed with Cochran <svg height="4.5999999" id="M269" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.825 4.5999999" width="10.825" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">−</tspan>
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</svg> test(<svg height="4.5999999" id="M270" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.825 4.5999999" width="10.825" xmlns="http://www.w3.org/2000/svg">
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</svg>). Summary: OR = 1.24 (95% CI = 1.06–1.45).</table>

Journal of Nucleic Acids

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Figure 2

Figure 2: Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis 