Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

Table 1

The details of the OGG1, XRCC1, XPA, and ERCC/2XPD genes.

Gene symbol	Gene name	Gene location	Polymorphism	DNA repair capacity
OGG1	8-oxoguanine DNA glycosylase	3p26.2	Ser326Cys (rs1052133)	The Cys/Cys genotype may be associated with a lower DNA repair capacity
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	19q13.2	Arg194Trp (rs1799782), Arg280His  (rs25489), Arg399Gln (rs25487)	Although the Arg399Gln, Arg194Trp, and Arg280His polymorphisms have been suggested to be functional, there is no direct evidence on its functional consequences
XPA	Xeroderma pigmentosum, complementation group A	9q22.3	G23A (rs 1800975)	The G allele may be associated with a higher DNA repair capacity
ERCC2/XPD	Excision repair cross-complementing group 2/ Xeroderma pigmentosum, complementation group D	19q13.3	Asp312Asn (rs1799793), Lys751Gln (rs13181)	The 312Asn and 751Gln alleles are reported to be associated with lower DNA repair capacity