| | Author, published year (reference no.) | Ethnicity | No. of Cases/Controls | Source of controls | OR (95% CI) |
Quality control of genotyping | | Arg/Gln | Gln/Gln | |
| | Ratnasinghe et al., 2001 [34] | Asian | | Population | 1.00
(0.60–1.60) | 1.40
(0.50–1.70 |
Replication (random sample) | | David-Beabes and London, 2001 [35] | African-American | | Population | 1.03
(0.66–1.60) | 0.52
(0.14–1.97) |
Replication (random sample) | | David-Beabes and London , 2001 [35] | Caucasian | | Population | 0.75
(0.52–1.08) | 0.63
(0.34–1.14) |
Replication (random sample) | | Divine et al., 2001 [36] | Caucasian | | Hospital | 0.76
(0.47–1.22) | 1.64
(0.80–3.36) |
None | | Chen et al., 2002 [37] | Asian | | Population | 1.02
(0.57–1.80 | 0.67
(0.20–2.26) |
None | | Park et al., 2002 [38] | Asian | | Hospital visitors | 1.27
(0.81–2.04) | 2.30
(0.87–6.09) |
Sequencing | | Misra et al., 2003 [39] | Caucasian | | Population | 1.10
(0.78–1.54) | 0.84
(0.45–1.58) |
Replication (random sample) | | Zhou et al., 2003 [40] | Caucasian | 1,091/1,240 | Hospital visitors | 1.00
(0.80–1.20) | 1.30
(1.00–1.70) |
Replication (random sample) | | Ito et al., 2004 [41] | Asian | | Hospital | 1.01
(0.70–1.45) | 1.39
(0.70–2.76) |
None | | Popanda et al., 2004 [42] | Caucasian | | Hospital | 0.89
(0.67–1.17) | 0.87
(0.58–1.29) |
Replication (random sample) | | Harms et al., 2004 [43] | Caucasian | | Hospital | 0.73
(0.44–1.25) | 1.07
(0.39–2.96) |
Replication (all samples) | | Zhang et al., 2005 [44] | Asian | 1,000/1,000 | Hospital | 0.95
(0.79–1.14) | 1.14
(0.84–1.55) |
Replication (all samples) | | Hung et al., 2005 [25] | Mostly composed of Caucasians | 2,049/2,015 | Hospital | 1.12
(0.98–1.28) | 1.01
(0.83–1.23) |
Replication (random sample) | | Vogel et al., 2004 [23] | Caucasian | | Population | 0.79
(0.54–1.17) | 0.81
(0.46–1.41) |
Replication (random sample) | | Schneider et al., 2005 [45] | Caucasian | | Hospital | 0.94
(0.72–1.23) | 0.83
(0.54–1.26) |
None | | Shen et al., 2005 [46] | Asian | | Population | 0.59
(0.33– | .75
(0.13–4.23 |
None | | Zienolddiny et al., 2006 [26] | Caucasian | | Population | 1.08
(0.78–1.49 | 0.67
(0.39–1.14 |
Replication (all samples) | | Matullo et al., 2006 [27] | Caucasian | 116/1,094 | Population | 1.14
(0.75–1.73 | 0.52
(0.19-1.19 |
Replication (random sample) | | Yin et al., 2007 [47] | Asian | | Hospital | 1.20
(0.77– | 0.21
(0.05– |
None | | López-Cima et al., 2007 [48] | Caucasian | | Hospital | 0.91
(0.70–1.20) | 0.89
(0.61–1.31) |
Sequencing | | Pachouri et al., 2007 [49] | Asian | | Population | 0.36
(0.20–0.64) | 0.47
(0.20–1.09) |
None | | De Ruyck et al., 2007 [30] | Caucasian | | Hospital | 1.28
(0.69–2.28) | 1.68
(0.67–4.23) |
None | | Chang et al., 2009 [33] | Latino | | Population | 1.30
(0.73–2.30) | 3.03
(1.11–7.83) |
Replication (random sample) | | Chang et al., 2009 [33] | African-American | | Population | 1.02
(0.62–1.65) | 1.19 (0.24–5.13) |
Replication (random sample) |
| | Summary | No. of populations | | | | |
Cochran test for heterogeneity | | | | | | | Arg/Gln | Gln/Gln |
| | All | 24 | 8,684/10,913 | | 0.97
(0.89–1.05) | 1.00
(0.86–1.17) | 0.153 | 0.004 | | Caucasian (mostly composed of Caucasians) | 13 | 6,154/7,769 | | 1.00
(0.92–1.08) | 0.95
(0.83–1.10) | 0.433 | 0.218 | | Asian | 8 | 2,010/2,325 | | 0.90
(0.72–1.13) | 1.08
(0.78–1.49) | 0.024 | 0.030 |
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