Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

Table 4

Genetic polymorphisms in the BER pathway and lung cancer risk: XRCC1 Arg194Trp polymorphism.

Author, published year (reference no.)	Ethnicity	No. of; Cases/control	Source of controls	OR (95% CI)∗		Quality control of genotyping
				Arg/Trp	Trp/Trp
Ratnasinghe et al., 2001 [34]	Asian	108/216	Population	0.70; (0.40–1.20)	0.70; (0.30–1.60)	Replication (random sample)
David-Beabes and London, 2001 [35]	African-American	154/234	Population	0.40; (0.19–0.83)	1.44; (0.20–10.37)	Replication (random sample)
David-Beabes and London, 2001 [35]	Caucasian	180/461	Population	1.05; (0.62–1.78)	109/109	Replication (random sample)
Chen et al., 2002 [37]	Asian	)	Population	1.31; (0.73–2.32)	2.61; (0.85– 8.04)	None
Hung et al., 2005 [25]	Mostly composed of Caucasians	2,147/2,132	Hospital	0.86; (0.72–1.03446/622	0.81; (0.35–1.88)	Replication (random sample)
Schneider et al., 2005 [45]	Caucasian	)	Hospital	0.99; (0.67–1.46)	1.86; (0.31–12.8118/112	None
Shen et al., 2005 [46]	Asian	336/405	Population	1.01; (0.56–1.83)	1.48; (0.51–4.45)	None
Zienolddiny et al., 2006 [26]	Caucasian	0	Population	0.88; (0.50–1.55)	116/1094.60; (0.01–11.5)	Replication (all samples)
Matullo et al., 2006 [27]	Caucasian	)	Population	1.10; (0.59–1.94)	9.70; (0.69–134.6241/249	Replication (random samples)
Yin et al., 2007 [47]	Asian	)	Hospital	0.89; (0.60–1.321	).09; (0.54–2.18‡	None
Pachouri et al., 2007 [49]103/122	Asian	1.	Population	0.97; (0.54–1.76)	)36; (0.67–2.75110/110	None
De Ruyck et al., 2007 [30]	Caucasian	112/296	Hospital	0.43; (0.15–1.12)	254/280	None
Chang et al., 2009 [33]	Latino	∗∗	Population	0.73; (0.37–1.49)	𝑄	Replication (random samples)
Chang et al., 2009 [33]	African-American	†	Population	1.23; (0.64–2.30)	576/686	Replication (random samples)
Summary∗	No. of populations					Cochran ∗∗ test for heterogeneity
						Arg/Trp	Trp/Trp
All	13	4,431/6,320		0.89; (0.79–1.00)^†𝑃=.047.	1.15; (0.80–1.67)	0.467	0.510
Caucasian (mostly composed of Caucasians)	6	3,335/4,824		0.89; (0.77–1.03)	1.24; (0.50–3.11)	0.653	0.315
Asian	4	‡		0.93; (0.72–1.20)	1.18; (0.72–1.93)	0.476	0.305

95%Crude odds ratio and 95% confidence interval.
∗Based on random effects model.
106/209
309/302Excluded from the meta-analysis because genotype distribution of control population was not in Hardy-Weinberg equilibrium.