Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

Table 8

Genetic polymorphisms in the NER pathway and lung cancer risk: ERCC2 Lys751Gln polymorphism.

Author, published year (reference no.)	Ethnicity	No. of; Cases/controls	Source of controls	OR (95% CI)463/459		Quality control of genotyping
				Lys/Gln	Gln/Gln
David-Beabes et al., 2001 [64]	Caucasian	110/119	Population	1.14; (0.77–1.71)	1.72; (1.00–2.94)	Replication (random samples)
David-Beabes et al., 2001 [64]	African-American	256/269	Population	1.14; (0.73–1.78)	1.39; (0.54–3.55)	Replication (random samples)
Spitz et al., 2001 [55]	Admixed population	118/108	Population	1.07; (0.78–1.46)	1.36; (0.84–2.20)	None
Chen et al., 2002 [37]	Asian	‡	Population	0.79; (0.17–1.11)	0.44; (0.17–1.11)	None
Hou et al., 2002 [56]	Caucasian	317/386	Population	1.22; (0.75–2.00)	1.11; (0.58–2.13)	Replication (random samples)
Zhou et al., 2002 [57]	Caucasian	1,092/1,240	Population	1.01; (0.84–1.21)	1.17; (0.90–1.51)	Replication (random samples)
Park et al., 2002 [65]	Asian	116/1094	Population	1.06; (0.55–2.11)	975/997	None
Liang et al., 2003 [58]	Asian	1,006/1,020	Population	0.93; (0.73–1.18)	2.36; (0.90–6.17)	Replication (random samples)
Misra et al., 2003 [39]	Caucasian	110/109	Population	0.87; (0.60–1.26)	1.06; (0.64–1.76)	Replication (random samples)
Popanda et al., 2004 [42]	Caucasian	/533	Hospital	1.14; (0.86–1.52)	1.37; (0.93–2.02)	Replication (random samples)
Harms et al., 2004 [43]	Caucasian	113/299	Population	1.34; (0.79–2.49)	1.07; (0.34–3.38)	Replication (all samples)
Vogel et al., 2004 [59]	Caucasian	255/280	Population	1.57; (1.05–2.34)	1.73; (1.01–2.96)	None
Shen et al., 2005 [60]	Asian	285/285	Population	0.44; (0.18–1.03)	∗∗	Replication (random samples)
Zienolddiny et al., 2006 [26]𝑄	Caucasian	20(18)	Population	1.20; (0.84–1.73)	1.56; (1.06–2.31)	Replication (all samples)
Matullo et al., 2006 [27]	Caucasian	0.613	Population	1.23; (0.78–1.96)	1.17; (0.63–2.11)	Replication (random samples)
Hu et al., 2006 [61]	Asian	0.727	Hospital	1.16; (0.89–1.52)	1.46; (0.40–5.87)	None
De Ruyck et al., 2007 [30]	Caucasian	10	Hospital	1.07; (0.58–1.97)	1.46; (0.55–3.94)	None
López-Cima et al., 2007 [48]	Caucasian	516†	Hospital	1.08; (0.83–1.41)	1.25; (0.80–1.95)	Sequencing
Chang et al.,2008 [62]	Latino	0.702	Population	1.01; (0.61–1.66)	2.89; (1.20–6.91)	Replication (random samples)
Chang et al., 2008 [62]	African American	0.973	Population	1.20; (0.83–1.74)	1.01; (0.41–2.43)	Replication (random samples)
Yin et al., 2009 [63]	Asian	6(4)	Hospital	1.68; (1.06–2.67)	1.47; (0.24–10.1)	Replication (random samples)
Summary0.085	No. of populations					Cochran 0.096 test for heterogeneity
						Lys/Gln	Gln/Gln
All	∗	6,941/8,595		1.09; (1.04–1.18)	1.27; (1.10–1.46)	∗∗	†
Caucasian	𝑃=.051	3,336/4,740		1.10; 0.99–1.22)‡	1.24; (1.06–1.45)	𝑄	𝑄=2.75,𝑃=.97
Asian	OR=1.24	2,743/2,682		1.04 (0.81–1.35)	1.16 (0.48–2.80)	𝑄	OR=1.22

Crude odds ratio and 95% confidence interval. OR=1.43 Based on random effects model. OR=1.5 OR=0.76
5^ Excluded from the meta-analysis because genotype distribution of control population was not in Hardy-Weinberg equilibrium.